Barca have dropped points in three successive LaLiga matches after a 2-2 draw at home to Girona and the midweek 2-1 defeat away to Leganes.
Barcelona are in a real spot of bother right now.
Leganes goalkeeper Ivan Cuellar pulled off a stunning double save to thwart Coutinho and Ivan Rakitic from close range in the closing minutes while Sergi Roberto skied a good opportunity as the unfancied hosts held on to record their first top-flight win over Barcelona.
"I have to judge the games we have coming up and we have four games in the space of 10 days, I have to think about what might happen and I thought Leo and Busquets had to rest, knowing that we have a very tough game on Wednesday and we have a large squad", Valverde said.
Messi came on in the second half and grabbed the assist for Munir El Haddadi's equaliser at the Camp Nou.
Leganes climbed off the foot of the table as they fought back from an early goal down to beat Barcelona 2-1 at Butarque on Wednesday. We have to be more solid.
"We should have won the game before he came on". "It's a really negative result".More news: Lil Wayne to mark this birthday with a new album this week
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"Against Leganes we played well in the first half and lost, and today we created chances to win but couldn't".
"Sometimes it's hard to explain what happens in a game".
"This is Barca. We have enough players, we don't need to depend on one". At 1-0 you're close to an accident. "That's five points in three days gone and it's hard to explain".
"I always do that before playing games, I can't do it afterwards or rewind".
Argentina skipper Lionel Messi has reportedly advised his club FC Barcelona to make a move for Spanish youngster Oscar Rodriguez, who now plays for another La Liga side Leganes on loan from Catalan's arch-rivals Real Madrid, reports Spanish outlet, Don Balon.
Brazil midfielder Phillipe Coutinho also struck a shot onto the crossbar and Luis Suarez was unable to convert the follow-up.