In response, Iran's Foreign Minister Mohammad Javad Zarif said that the support of European officials would be insufficient without the United States, and implied that Europe was not doing enough to preserve the deal's benefits for Iran.
"Pompeo's [strategy] which reflects the determination to confront the danger of Iranian policies that undermine security and stability in the region and to overcome the shortcomings of the nuclear agreement. It aspires to achieve nuclear weapons by various means", Netanyahu said as he met Paraguayan President Horacio Cartes in Jerusalem.
State Department officials say the aim of the speech is to outline a path forward after Trump announced he would withdraw the USA from the 2015 landmark nuclear deal with Iran and reimpose sanctions, a decision that immediately puts the United States in breach of its commitments.
Other demands the Iranians are unlikely to go along with include stopping uranium enrichment and ballistic missile tests, and allowing global inspectors access to all sites, including military locations where critics suspect clandestine research. Iran would also have to walk away from core pillars of its foreign policy, including its involvement in Syria, Yemen, Lebanon and Afghanistan.
"The list of requirements of the Iranians asks for everything but conversion to Christianity and reads more like a demand for unconditional surrender than an actual attempt at negotiation", said Jeremy Shapiro, research director at the European Council on Foreign Relations. "This is the right policy".
The secretary of state's speech Monday at the Heritage Foundation in Washington gave European leaders little reason to hope Washington will show flexibility in dealing with their companies that want to continue investing in the Islamic Republic.
The prime minister said that if Tehran genuinely wanted to pursue a peaceful nuclear program, it would "not need a single centrifuge". Even though US negotiators tried to get Iran to admit it tried to build one in the early 2000s, Tehran refused.
The deal was created to prevent Iran from developing a nuclear weapon. The move came shortly after Netanyahu said earlier this month that Israel had obtained 100,000 paper and digital documents, which, he said, irrefutably prove that Iran's nuclear program had a secret military component, codenamed "Project Amad".More news: Senate backs effort to restore 'net neutrality'
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In his remarks, Pompeo had threatened punishing sanctions against Tehran unless it amends its ways.
U.S. sanctions lifted after the 2015 deal will be re-imposed, Mr Pompeo said, and those and new measures will together constitute "unprecedented financial pressure on the Iranian regime".
"Sanctions are going back in full effect, and new ones are coming", he warned.
Political analyst Jamal Abdi said the U.S. knew that Iran could never agree with such demands. Other analysts said the remarks amounted to a push for new leadership in Tehran and a return to traditional U.S. policy that could carry risks for the Trump administration. Iran, he added, was working with the other partners of the nuclear deal to find a solution.
"Who are you to decide for the world?" he told the Iranian media.
"We think that without this agreement we could run the risk that Iran could restart a nuclear programme", Maas said. "We will work to prevent and counteract any Iranian malign cyber activity".
"We will track down Iranian operatives and their Hizbollah proxies operating around the world and crush them", he said. Are these two not responsible for wasting Iranian lives through the Middle East?