Simeone watched his side draw a blank in Sunday's 0-0 draw with Real Betis, albeit with regular starters Antoine Griezmann, Koke and Diego Godin rested. Defender Diego Godin never left the bench.
Atletico Madrid star Jan Oblak has discussed his future amid speculation that Liverpool are interested in signing him. "Any worker is exhausted at this point". They were more dynamic and took the game to us.
Atletico failed to break through Betis' defense at the Wanda Metropolitano Stadium.
Betis lost goalkeeper Dani Gimenez to an apparent leg injury in the first half.
The news comes as a major blow as Elneny has been in great form recently and would have been a serious contender to keep his place in the middle of the park against Atletico so he'll be sorely missed.
Will you be resting players for the Europa League game?
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Barcelona's league match against Villarreal, and Madrid's game against Sevilla, were pushed back to May 9 due to the Copa del Rey final between Barcelona and Sevilla on Saturday.
Neville also reflected on Manchester City's 5-0 over Swansea and he was full of praise for Kevin De Bruyne, calling him a hybrid between Paul Scholes and David Beckham.
Las Palmas was relegated to Spain's second tier after losing 4-0 at home to Alaves. The Canary Islands club had spent three seasons in the top tier.
Arsenal supporters' liaison officer Mark Brindle said: "We know our match in Madrid is already shaping up to be an expensive one for our supporters with the early May Bank Holiday increasing travel costs".
Spanish media outlet AS claims that the Slovenia global has a €100 million (£87.5 million) inserted into his current contract with Atleti, and he still has three years remaining on his deal in the Spanish capital.
Both of Moreno's goals were set up by midfielder Sergi Darder.