Within a minute Arsenal found a way back into the game.
The 25-year-old arrived at the club in the summer of 2017 from Roma and has made an immediate impression at Anfield, scoring 20 goals in 26 appearances - a club-best figure.
Asked to choose a team alongside Phil Thompson, neither of the Sky Sports pundits selected Mesut Ozil or Alexis Sanchez in their teams. The pair have struggled in front of goal recently, however, Friday's game against a top-six rival could be the motivation needed to end their barren run.
Liverpool are now fourth in the Premier League, 18 points behind runaway leaders Manchester City in fourth, but the Merseysiders are the only team to have rivalled the exciting football from Pep Guardiola's men.
Liverpool have won 19 Premier League meetings with Arsenal winning 15 and 17 ending as a draw.
However, he has conceded 14 goals in his five games against Liverpool since joining Arsenal.
The big surprises in Nicholas' team were the choices of Joe Gomez at right-back, Dejan Lovren in central defence and Jack Wilshere in central midfield.More news: Raul Castro To Step Down in April 2018
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The Egypt global is the first player to reach that landmark for Liverpool since Luis Suarez in 2013-14, when they went agonisingly close to denying Manchester City the Premier League title.
Goals continued to flow, though, with Liverpool levelling through Firmino when Cech was unable to keep out the forward's effort despite getting a strong hand to the shot.
When these two teams met earlier this season, a much-hyped matchup gave way to Liverpool dominance and the worst Arsenal performance of the season.
Mohamed Salah says that he is confident Liverpool will know success in one of the competitions they are involved in this season.
Overall though, Liverpool have the edge against their North London counterparts, with 73 wins to Arsenal's 64.
When Xhaka took aim from 35 yards, the Arsenal midfielder's powerful effort appeared to move in the air, but it was still straight at Mignolet, who tried to make a fisted save but instead diverted the ball into the net.