Though Tottenham shouldn't lose all hope, last season Spurs did not lose a single game without Kane, managing to win five and draw three.
The last time they were victorious in successive league games was in the 1989-90 season, when they won 1-0 at Old Trafford on December 16 and 2-1 at home on April 21.
Tottenham and Manchester United share 20 equal points to sit third and second respectively in the EPL table separated by goal difference.More news: Pakistan opposes US-India Armed Drones Agreement
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After Man United's loss at Huddersfield, Alejandro Moreno blasts Jose Mourinho's constant changes to his system. Despite that, they will pose a huge threat at Old Trafford. Last season, both teams won their home fixtures against each other.
Toby Alderweireld is aware that he can't afford to make many mistakes against compatriot Romelu Lukaku when Tottenham Hotspur visit Manchester United on Saturday.
Tottenham manager Mauricio Pochettino then told his pre-match press conference on Friday: "For tomorrow, we can not take a risk".
He's also on top of the Premier League scoring charts with nine goals on the board.