"Our study found that consuming high-dose individual B6 and B12 vitamin supplements over a 10-year period is associated with increased lung cancer risk, especially in male smokers".
Regular taking of vitamins B6 and B12 in high doses were found to be most affecting smokers, who were found to 3-4 times higher risk of getting lung cancer. Taking B6 at this dose increased the lung cancer risk by three times and taking B12 at this dose increased it by four times.
It's also possible that this action from the B vitamins simply hastens the development of an underlying lung tumor already caused by smoking, Brasky says.
Their combined work is the first prospective, observational study to examine links between long-term high doses of B-6 and B-12 supplements and lung cancer risk. They were 89 percent more likely to get lung cancer than those who didn't take B12.
Researchers analyzed data from 77,118 participants in the Vitamins and Lifestyle (VITAL) cohort, a long-term prospective observational study created to evaluate the potential associations between cancer risk and use of vitamin or other mineral supplements. There were not enough cases of lung cancer among non-smokers to include them, and there was no increased risk seen in either women or vitamin B9.More news: Will eye damage follow the Great American Eclipse?
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The study was limited to roughly 77,000 Washington state adults, ages 50 to 76.
Over recent years, a number of studies have looked for links between lung cancer and B vitamins.
The researchers said, "The associations we observed provides evidence that high-dose B6 and B12 supplements should not be taken for lung cancer prevention and may, in fact, increase the risk of this disease in men". But high-dose supplements nowadays claim to boost energy, among other unproven benefits.
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James), Fred Hutchinson Cancer Research Center and National Taiwan University report their findings in the August 22, 2017 issue of the Journal of Clinical Oncology. "I think that the door remains open on that". Notably, smoking seemed to increase the chances of developing the disease significantly more when coupled with vitamin B supplements.
Why B vitamins influence cancer risk is not known for sure, but some believe that it is related to how B vitamins interact with the so-called one-carbon-metabolism pathway. Results revealed that just over 800 of the study volunteers developed lung cancer over an average follow-up of six years. In addition to complying with a host of federal and state regulations governing dietary supplements and food in the areas of manufacturing, marketing, quality control and safety, our manufacturer and supplier members also agree to adhere to additional voluntary guidelines as well as to CRN's Code of Ethics.