Of the other standout fixtures for Antonio Conte's side, Chelsea play Arsenal on September 16, host City on September 30 before United visit Stamford Bridge on November 4.
The full 2017/18 PL match fixtures can be seen here.
But it could prove a tricky opening few weeks for the defending champions too, with Chelsea hosting Everton (26 August), visiting 2015-16 winners Leicester after the worldwide break and then welcoming Arsenal (16 September).
Tottenham start the campaign with a trip to Newcastle United, their bogey team, aiming to exorcise the demons from their 5-1 defeat at St. James' Park on the final day of the 2015-16 season.
The weekend of December 9/10 sees Liverpool host Everton and City visit United in the first Manchester derby of the season. They will welcome Liverpool on October 21, a match that is followed by a trip to Manchester United. Liverpool will travel to the Emirates Stadium to face Arsenal just two days before Christmas whilst the Gunners will also host Antonio Conte's Blues on New Year's Day in what could be a crucial period for Wenger's men.More news: Democrats furious at evasive answers at hearing
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Huddersfield Town's first Premier League match will take place at Crystal Palace.
- Arsenal lost to West Ham and Liverpool in their last two opening-day games, but have not lost three in a row since 1960.
As for derbies, Arsenal have home advantage in the first north London showdown on November 18, with the return taking place at Wembley on February 10.
Brighton, meanwhile, are back in English football's top division for the first time since the 1982-83 season.
"We hoped to have one of the big clubs for our first home game".
Spurs are due to play Burnley at Wembley on August 26 but the fixture will be rescheduled because it is on the same day as the Rugby League Challenge Cup Final.
City also have a huge amount of time before they face any of the top sides, allowing their new signings to settle, with Chelsea away on the seventh weekend of the season their singular visit to one of last season's top seven before December hits.