There's still four games to go and France would still be post people's favourites, but what looked like a formality thirty seconds from the final whistle is now a significantly more challenging task.
In the wake of his country's defeat, former French worldwide and current manager of Les Bleus, Didier Deschamps, was asked about Lloris' mistake.
"We still have four games, we'll have to crack hard to reach our objective".
On 37 minutes, with the game goalless, Giroud picked up the ball just inside the box.
Arjen Robben and Wesley Sneijder scored first-half goals and Georgina Wijnaldum, Quincy Promes and Vincent Jannsen from the penalty spot netted after the break to give Advocaat an easy win in his first competitive match in charge on his return to the Oranje helm.More news: Australia look to find form in ICC Champions Trophy against Bangladesh
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Holland moved to within three points of the top two with a 5-0 win over Luxembourg in Rotterdam. If he clears the ball far and away, there is no way it comes back.
France started the second half brightly, with Griezmann having a header well saved by Robin Olsen after some good wing-play by Sissoko.
Making his national record 131st worldwide appearance - and on his 33rd birthday - attacking midfielder Wesley Sneijder made it 2-0 with a right-foot blast from outside the penalty area in the 34th.
Andorra stunned Hungary 1-0 to win their first World Cup qualifier in 13 years, ending a 66-match winless streak in official competitions.
"The match against Netherlands at Stade de France on August 31 was always going to be important". The other had come in a 2-1 home loss to Switzerland.
Naturally Sweden haven't been able to call on the services of veteran striker Zlatan Ibrahimovic since he retired in the wake of their early exit from last summer's European Championships, but it doesn't seem as though they're missing the 35-year-old.