Diódoro Carrasco, general secretary of the government of Puebla, told Cinco Radio: "Some of the injured were transferred to the capital Puebla during the night and dawn, at the moment there are 14 dead and 22 injured".
El Universal cited local officials as reporting someone threw a lit firework that landed inside a building behind the local church where the pyrotechnic materials for the celebration were being stored, causing a blast that seriously damaged the structure.
The explosion in the village of San Isidro, 270 kilometers east of Mexico City, came during preparations for a religious festival on May 15, the state government said.
The house was destroyed and nine people were killed, three more died in hospital.
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Five months after more than 30 people were killed and 70 injured by a similar explosion in a fireworks market at the northern edge of Mexico City.
State governor Antonio Gali Fayad said he had ordered the authorities "to see to the wounded and give the village of San Isidro all the help necessary". The market was well stocked with fireworks at the time and there were hundreds of customers.
Mexico and many other Latin American countries often use fireworks as part of celebrations throughout the year. It was reduced to smoldering ruins.
The San Pablito market had been rocked by two explosions in the past: In September 2005 ahead of the Independence Day holiday, and again the following year. The areas where the recent fireworks explosions have happened in Mexico are some of the most popular fireworks makers in the country.
The fireworks industry brings in almost $10 million a month in revenue in Mexico, authorities say.