Robert Lewandowski bagged a brace, David Alaba fired home a free kick to get the goals flowing, Arjen Robben pulled out a party piece from range and Thomas Müller was in the right place at the right time to hoover up a goal when Lewandowski could only hit the woodwork.
No team had ever won the Bundesliga more than three times in a row before Bayern Munich extended it to four a year ago.
It also goes a small way towards making up for the disappointment of going out in the quarter-finals of the Champions League to Real Madrid.
It was game over before the break when Coman - who this week agreed to join Bayern on a permanent deal from Juventus for next season - turned away from Didavi and cut back for Lewandowski to drill home a third. "And now we have won it for the fifth straight time".
The second leg was arguably one of the best games of football to be played anywhere in the world this season, as the two European heavyweights traded blow after blow at the Santiago Bernabeu.
"The league is the most honest of titles", said Bayern's chief executive Karl-Heinz Rummenigge.
"It is wonderful what this team did again this season in the Bundesliga", said the retiring Bayern captain, Philipp Lahm.
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Lewandowski extended his brilliant record against Wolfsburg as his first-half double made it 10 goals in his past four matches against them.
A thundering finish from the angle from Joshua Kimmich applied the finishing touches with the final goal of the evening on 85 minutes.
"I want to thank this great club", he said.
Ancelotti has now won four national league titles after also lifting the Premier League with Chelsea, Serie A with AC Milan and Ligue 1 with Paris Saint Germain.
Bremen maintained their stunning recent form, which now features nine wins and two draws from their last 11 league games and has transformed them from relegation battlers to contenders for Europe.
Borussia Dortmund failed to take a firm grip on third place as they were held to a goalless home draw by Cologne.
Werder striker Max Kruse's dream April continued as he netted Bremen's second after Fin Bartels's opener for his eighth goal in six games this month.
A shock defeat at Rostov all but ended Bayern's hopes of finishing top of their Champions League group, and so it proved despite a 1-0 home victory over Atletico in early December.